Message: Eating less can make the aging process healthier and even delay it
Markers of aging, e.g., so called 5-methylcytidine and DNA methyltransferase, can be substantially decreased in mice hippocampus by a simple mild limitation of access to food. Hippocampus is a structure, which actively participate with the processes of learning, memory, and cognition. Authors of the paper recently published in “Current Alzheimer Research” concluded: “These findings indicate that the aging process in mice is connected with profound changes in the epigenetic machinery in the hippocampus. Whether the observed epigenetic patterns associated with calorie restriction mediate the beneficial effects on the life-span remains to be elucidated.”
Source: Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction. Curr Alzheimer Res. 2012 Jan 23.